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Abstract Introduction: Transcatheter arterial chemoembolization (TACE) is widely utilized in the treatment of malignant liver tumors. By interrupting the arterial supply, chemoembolization deprives the tumor of its major nutrient source, which ends up in ischemic tumor necrosis. Aim of the Work: To identify the anatomical variations in the hepatic arterial system in Hepatocellular carcinoma patients. Patients and Methods: 64 Egyptian patients were retrospectively analyzed came for triphasic CT of the liver.The celiac trunk and its main branches mainly the common hepatic artery were detected.The incidence of different celiac and hepatic artery anomalies was calculated depending on Michel’s and Adachi’s classifications. Results: In total, 64 patients were enrolled in the study, the mean age of this study population is 63.95 years. It was identified normal hepatic arterial anatomy in 37 patients (57.8%). The other 27 patients (42.2%) showed some variation. Regarding Michels classification, the most frequently observed abnormalities were: right hepatic artery branch of the superior mesenteric artery (Type III, n=10, 15.6 %); left hepatic artery branch of the left gastric artery (Type II, n=8, 12.5%); Accessory left hepatic artery of the left gastric artery (Type V, n=5, 7.8%). Accessory right hepatic artery of the superior mesenteric artery (Type VI, n=2, 3.1%). Replaced right hepatic artery of superior mesenteric artery and Accessory left hepatic artery of the left gastric artery (Type VIII, n=2, 3.1%). While, concerning Adachi classification, It was identified normal trifurcation of the celiac trunk (hepatogastrosplenic) hepatic arterial anatomy in 62 patients (96.9%). The other 2 patients (3.1%) showed type II (hepatosplenic) variation |