الفهرس 
Serum erythropoietin level for detection of kidney and brain injuries in asphyxiated neonates in neonatal intensive care unit
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Abstract
Background: Perinatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of brain injury in the newborn and can result in long-term devastating consequences. Acute kidney injury (AKI) occurs in (50 {u2013} 72%) among asphyxiated term infants. Erythropoietin (EPO) is a hormone secreted by the kidney that stimulates the bone marrow for RBCs formation. The erythropoietin-producing kidney cells are sensitive to low oxygen levels in the blood that passes through the kidney.The aim of our study is to evaluate brain injury in full-term neonates with perinatal asphyxia by detecting specific biomarkers in the blood during fist days of life (erythropoietin). And evaluate kidney injury related to perinatal asphyxia. Materials and methods: A cross-sectional study included 80 full-term neonates in their first 96 hours of life: 40 healthy neonates, 14 newborns with clinical signs of mild HIE, 15 newborns with moderate HIE, 11 newborns of severe HIE. To study serum erythropoietin level for detection of kidney and brain injuries in asphyxiated neonates.Results: In our study we found that serum erythropoietin level was significantly higher in patients{u2019} group than control group. Serum erythropoietin level was significantly higher in severe cases of HIE than mild and moderate cases. In our study we found high serum creatinine level in patients group compared to controls group and this may reflect effect of hypoxia on kidney function. 50 % of asphyxiated neonates were found to have AKI, and 95% were non-oliguric. In our study we found there was no significant difference between AKI group compared to non-AKI group as regard serum erythropoietin level. ROC curves were plotted for erythropoietin. Erythropoietin level greater than 10.5 mIU\ml showed a sensitivity of 67.5% and specificity of 82.5% and area under curve (AUC) of 70.0%