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Abstract Background: Bariatric surgery is considered a successful modality for long-term maintaining weight loss, Rapid weight loss following these procedures is associated with increased incidence of postoperative Cholelithiasis (CL).Postoperative use of ursodeoxycholic acid (UDCA) was advocatedto prevent gallstone formation during the postoperative period and to avoid the unnecessary morbidities that occur with routine prophylactic cholecystectomy performed in bariatric surgery patients even in absence of gallstones. The aim of this study was to evaluate the role of daily administration of ursodeoxycholic acid (UDCA) for 6 months in the prevention of CL after laparoscopic sleeve gastrectomy Methods This was a prospective randomized control trial of 80 morbidly obese patients who underwent laparoscopic sleeve gastrectomy after preoperative ultrasonographic exclusion of gallstones. Patients were subdivided into two groups: control group (No UDCA group) who did not receive prophylactic treatment with UDCA, and UDCA group, who received 500mg of UDCA therapy for 6 months postoperatively.Patient{u2019}s characteristics, weight loss data, any detectable complications and incidence of CL at 6 ,12, and 18 months postoperatively were collected |