الفهرس 
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Abstract
Autoimmune hepatitis (AIH), Primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC) are chronic liver diseases (CLDs) likely to have an autoimmune basis to their pathogenesis. Their etiology largely remains obscure. There is increasing interest in the study of the epidemiology of autoimmune liver diseases (AILDs), as if diagnosed early and treated appropriately, patients‟ longevity can be prolonged and requirement of liver transplantation may be reduced. The current study was conducted at Al-rajhi Liver Hospital in period between 2015 and 2018. During the study period, 1750 patients were admitted to hospital with different liver disease regardless frequency of hospitalization where many patients had frequent times of hospitalization. Out of the study, only 50 (2.9%) patients were diagnosed to have different forms of autoimmune liver diseases. During the study analysis, all other patients with other types of liver disease (1700, 97.1%) were excluded. Mean age of enrolled patients was 37.50 ± 11.05 years with range between 16 and 56 years. With exception of only 9 male patients, all other patients were females. Mean duration of the disease was 2.48 ± 1.55 year with range between one year and 6 years. The most frequent manifestations among enrolled patients were jaundice (92%), fatigue (84%) and abdominal pain (40%). Itching was experienced in 15 (30%) patients. The current study revealed that autoimmune hepatitis was diagnosed in 40 (80%) patients. Six (12%) patients were diagnosed to have primary sclerosing cholangitis while 4 (8%) patients had primary biliary cirrhosis In conclusion, autoimmune liver diseases are not uncommon and the spectrum of autoimmune liver diseases does not differ from that reported in Western literature. Autoimmune liver diseases are often recognized late. To detect them early, they should be suspected in all patients with chronic liver diseases, especially in middle-aged women who do not have problems with alcoholism and who are without viral etiology. Presence of the known autoimmune diseases should alert clinicians to look for autoimmune liver diseases in these patients. Based on the current study, it’s recommended to; Perform such studies in large sample of population in multi centres Comparison between different available lines of therapy for autoimmune liver diseases. Any case with unexplained liver function abnormality should be managed with multidisciplinary team for possibility of autoimmune liver diseases.