الفهرس | Only 14 pages are availabe for public view |
Abstract Aloe vera (Aloe barbadensis) is one of the herbal remedies with a longstanding history for its curative properties for various ailments and it is one of the richest natural sources of health for human beings. The chemistry of the plant has revealed the presence of many different biologically active substances such as vitamins, enzymes, minerals, polysaccharides, and amino acids etc... According to the World Health Organisation (WHO), medicinal plants would be the best source for obtaining a variety of drugs. Numerous studies worldwide indicate that aloe vera is helping to fight illness of all kinds .Aloe vera is one such plant being studied extensively for cancer prevention. The goal of this study is to evaluate the chemical composition of aloe vera gel as well as its antioxidant, antimicrobial, antitumor activities. The obtained results revealed that the moisture content, crude protein, crude fiber, pH and TSS of gel were 97.25%, 0.09%, 0.36%, 3.74 and 1.00, respectively. The results obtained by (HPLC) of aloe vera extracts identified and quantified 26 phenolic and 11 flavonoid compounds. Epi-catechin, catechin and catechol were the highest phenolic compounds in all extracts while hesperidin and naringin were the highest flavonoid compounds in the methanol extract of aloe vera . The antimicrobial activities showed high effect against both gram positive and gram negative bacteria. The aloe vera gel significantly inhibited the growth of all tested fungi and yeast.The effect of aloe vera was studied against HepG2, Caco, Hela and MCF7 cells. The results of cytotoxicity revealed significant difference between all the tested compounds. The drug A (aloe vera gel) showed the highest toxicity in all cell lines used in the experiment and showed very high toxicity on HepG2 (1.2±0.2). The lowest toxicity was observed on hela cell line when treated by all tested compound. It coud be concluded from the results of this research that aloe vera is one of the most promising plants with high antioxidant, antimicrobial, anti-cancer properties |