الفهرس 
Title:Impact of Microbial Infection on Epithelial Mesenchymal Transition mechanism as a Vehicle of Bladder Cancer Metastasis: A Molecular Biology Study
AbstractOnly 14 pages are availabe for public view
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Abstract
ROS levels are triggered in cancer cells because of bacteria that led to increase in UCP2 to adjust ROS levels. This enhances PDK1 to downregulate PDH in order to block OXPHOS in favor of glycolysis. That results in aberration in mitochondrial function and decrease of AMPK enzyme, while MCT1 elevates to be able to export the produced lactate to ECM. ECM now became more acidic and ready for morphological changes. This process occurs concomitantly with EMT as it provides the cell rapid ATP and energy required for transdifferentiation like EMT and stemness