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العنوان
Platelet-rich plasma vs hyaluronic acid treatment in symptomatic patients with knee osteoarthritis /
الناشر
Tamer Yahia Tolba Elsayed ,
المؤلف
Tamer Yahia Tolba Elsayed
هيئة الاعداد
باحث / Tamer Yahia Tolba El Sayed
مشرف / Ahmed Kholeif
مشرف / Sherif Khaled
مشرف / Mohamed Samir Gobba
تاريخ النشر
2020
عدد الصفحات
112 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
جراحة العظام والطب الرياضي
تاريخ الإجازة
6/12/2020
مكان الإجازة
جامعة القاهرة - كلية الطب - Orthopedic surgury
الفهرس
Only 14 pages are availabe for public view

from 140

from 140

Abstract

Introduction: Knee cartilage, a sort of hyaline cartilages known for its unique properties, enables almost frictionless joint movement and protects the underlying bone from excessive load and trauma by dissipating the forces produced during movement. However, cartilage has limited intrinsic healing potential because it is avascular and has few specialized cells with a low mitotic activity. Aim: the aim of the study is to compare results after intra-articular injections of either platelet-rich plasma (PRP) or Hyaluronic Acid (HA) to treat knee osteoarthritis. Subjects and methods: This study was a randomized controlled trial including fifty patients suffering from knee OA. Patients were randomly assigned to receive PRP or HA. Intra-articular injection was given in two doses at 4-week interval in the PRP group (n = 25) and three doses of intra-articular injection at 1-week interval in between in the HA group (n = 25). All patients were evaluated before and at 6 months after treatment by International Knee Documentation Committee (IKDC) score and imaging. Results: The mean Post-injection IKDC subjective score were 64.08±3.22 and 63.84±3.35 in PRP and HA group, respectively with no statistically significant difference (p=0.798). Post-injection cartilage thickness was 2.11±0.9 and 2.09±0.8 in PRP and HA group, respectively with no statistically significant difference (p=0.061)