الفهرس 
Title : Evaluating the effect of desflurane versus sevoflurane withrecent biomarkers of renal and hepatic function in laparoscopic cholecystecomy patients
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Abstract
Background: Exposure to inhalational anesthetics is associated with hepatic and renal changes. aim: To compare sevoflurane (S) versus desflurane (D) with more sensitive and specific biomarkers of hepatic and renal functions in patients undergoing elective laparoscopic cholecystectomy. patients and methods: A prospective randomized study with 70 patients (D, n = 35 and S, n = 35). Neutrophil Gelatinase Associated Lipocalin, Cystatin-C, Arginase, liver (AST, ALT) and kidney function tests (BUN and creatinine) were assayed.results: High serum NGAL levels suggest the possibility of subclinical renal injury in the desflurane group, but with no renal clinical adverse effects.The specific biomarkers showed early elevations at 1 hour postoperatively for cystatin and 1 to 6 hours postoperatively with arginase in both groups, with no adverse clinical renal or liver effects. conclusion:This study confirmed that sevoflurane and desflurane provide safe anesthetic profiles regarding renal and hepatic integrity during limited duration laparoscopic procedures. Sevoflurane and desflurane had no adverse clinical effects in these patients undergoing laparoscopic cholecystecomy. Wide scale studies comprising larger numbers of patients should be performed to assess the microscopic effects on hepatic and renal integrity using sevoflurane and desflurane during longer periods of exposure to pneumoperitoneum and volatile anesthetics