الفهرس 
Reactivity of Direct Acting Antiviral Drugs Against Human Coronaviruses
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Abstract
Background: Coronaviruses (CoVs) are a group of positive-sense, single-stranded RNA viruses that infect avian species and many mammals, including humans, bats, and camels. Aim: The Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes severe acute, deadly, pneumonia. Papain-like protease (PLpro), is a human coronavirus cysteine protease encoded within the Non-Structural protein 3 (nsp3). Testing possible PLpro inhibitors can lead to a potential cure and save lives. Materials and Methods: Molecular docking is performed to test the binding performance of six protease inhibitors against MERS CoV PLpro. Results: The compound, GRL-0667, shows the highest binding affinity to MERS CoV PLpro, while the interaction pattern in the case of Hepatitis C Virus (HCV) non-structural protein 3 (NS3) is the same as in the case of coronaviruses. Conclusion: The present study shows the ability of some anti-SARS CoV PLpro and anti-HCV NS3 drugs to inhibit MERS CoV PLpro.