الفهرس 
Phenotypic and genotypic investigations ofcarbapenem resistance of certain Gram-negative bacterial pathogens in Egypt
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Abstract
Purpose: This study aimed to detect the prevalence of carbapenemase producers (CPs) among extensive drug-resistant (XDR)Gram negative bacteria (GNB) recovered from various clinical specimens of hospitalized neutrophilic febrile patients in two major tertiary care hospitals in Egypt. Methods: Standard methods were used to evaluate the antimicrobial susceptibility of clinical isolates according to the guidelines of the Clinical and Laboratory Standards Institute (CLSI). Phenotypic and genotypic analysis of CPs were carried out and statistically analyzed using standard methods.Results: A number of 342 GNB were obtained from the 342 clinical specimens during the period of the study, where 162 (47%) were enterobacterial isolates and 180 (53%) were non-fermentative bacilli. Out of the 342 GNB; 188 (54.9%) isolates were MDR. Among these, 52 (27.6%) were XDR as well as CPs as confirmed phenotypically.The most prevalent CR genes were blaKPC (63.5%) followed by blaOXA-48 (55.7%) and blaVIM (28.8%). However, neither blaIMP norblaNDM could be detected.No significant association could be noticed between the MIClevel of CR and presence of CR genes(Pvalue >0.05)