الفهرس 
The effectiveness of physical therapy interventions for fatigue in multiple sclerosis patients
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Abstract
Objective: The aim of this systematic review was to examine the effectiveness of physical therapy interventions for fatigue in multiple sclerosis patients. Subjects and Methods: The current study was made on patients with multiple sclerosis aged {u2265}18 years. We searched the PubMed, Pedro, Cochrane and goggle scholar web site from inception up till now. Systematic review of randomized controlled trials, the intervention used was Physical therapy interventions as a group programs.Nine studies were selected according to inclusive and exclusive criteria and descriptive analysis were conducted due to heterogeneity. Outcomes Fatigue Severity Scale (FSS), Modified Fatigue Impact Scale (MFIS), Visual Analogue Scale (VAS), and MS Quality of Life 54 (MSQoL-54). Results: Seven studies assessed fatigue by fatigue severity scale.There was very high heterogeneity in fatigue severity scale among studies (n= 7studies, n= 941participants, P<0.00001; I2=95%). There was significant overall effect between exercise therapy group and control group in fatigue by fatigue severity scale (SMD= -1.24; 95% CI, -1.38 to-1.10; P<0.00001), Two studies assessed fatigue by modified fatigue impact scale.There was very high heterogeneity in modified fatigue impact scale among studies (n= 2studies, n= 131participants, P=0.004; I2=88%).There was significant overall effect between exercise therapy group and control group in fatigue by modified fatigue impact scale (SMD= -0.57; 95% CI,-0.93 to -0.22; P=0.002) Three studies assessed fatigue by visual analogue scale. There was very high heterogeneity in visual analogue scale among studies (n= 3studies, n= 234participants, P<0.00001; I2=98%)