الفهرس 
Expression of B7-H1 in colorectal epithelial neoplasms
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Abstract
Background: Colorectal carcinoma CRC is the third most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide and a leading cause of cancer related deaths. Conventional (tubular, tubulovillous and villous) adenomas are the most common neoplastic lesions occurring in the large intestine.Based on insight into immune system / cancer interactions, cancer immunotherapy strategies have been developed. Of these strategies, immune checkpoints regulators are among the most important. B7-H1 2programmed Death Ligand 1 (PD-L1)3 is one of the 2 ligands of Programmed Death-1 (PD-1); an important immune checkpoint regulator. Clinical trials using PD-L1 antibodies have shown efficacy in various cancers.Objectives: Detection of immunohistochemical (IHC) expression of B7-H1 by tumor cells (TC) and stromal tumor infiltrating lymphocytes (I) in colorectal adenocarcinoma, adenomatous polyp and ulcerative colitis and correlation of this expression with the clinico-pathologic parameters. Materials and methods: 53 cases (30 colorectal adenocarcinoma, 18 colorectal polyp and 5 ulcerative colitis). IHC expression of B7-H1 was investigated in tumor or epithelial cells (T- epithelial) and lymphocytes or stroma (I- stroma)