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Abstract Purpose: This study was conducted to compare between efficacy of Endermologie versus low level laser on post mastectomy lymphedema. Subjects and methods: Thirty women participated in this study. Their ages ranged from 40 to 60 years. They were selected from Damanhour Oncology Centre and divided randomly into two groups equal in number. group (A): received 30 min Endermologie 3 times per week in addition to routine physical therapy program (manual lymphatic drainage, compression bandage, active range of motion and elevation), hygiene and skin care for 6 weeks. While, group (B): received 20 min Low Level Laser Therapy 3 times per week in addition to routine physical therapy program (manual lymphatic drainage, compression bandage, active range of motion and elevation), hygiene and skin care for 6 weeks. Upper limb lymphedema was evaluated by tape and volumetric assessment before and after the intervention. Results: This study revealed that there was a statistically highly significant decrease in mean value of circumferential measurements, volumetric measurements of group (A) when compared with its corresponding value in group (B). Conclusion: Endermologie was more effective than Low Level Laser Therapy in reducing limb circumference and volume in postmastectomy lymphedema |