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Abstract Background: One of the most frequent causes of vasculogenic erectile dysfunction (VED) is penile arterial insu{uFB03}ciency. Recently, low-intensity extracorporeal shock wave therapy (Li-ESWT) was reported to improve VED by enhancing perfusion of the penis. Purpose: The current study was performed to evaluate the efficacy of Li-ESWT in VED patients with penile arterial insufficiency. Materials and Methods: Single-arm study of sixty patients with a diagnosis of VED (penile arterial insu{uFB03}ciency) and failed to respond to phosphodiesterase type 5 inhibitors (PDE5is) or intracavernosal injection of vasoactive agents with five item version of the international index of erectile function (IIEF-5) score from 5 to 21, erection hardness score (EHS) of {u2264} 3 and peak systolic velocity of < 30 cm/sec. Li-ESWT treatment consisted of 3,000 shockwaves with an energy density of 0.09 mJ/mm2 twice weekly for 6 weeks. All patients continued their regular PDE5is use. The IIEF-5 questionnaire and EHS were used to evaluate the change in erectile function and the Penile Colour Doppler Ultrasonography was used to assess penile haemodynamic changes (erection grade, cavernosal artery diameter, peak systolic velocity and end diastolic velocity) before the first session, at the end of the last session, and follow up after 3 months. Results: The results showed that there was marked improvement in IIEF-5 score, EHS, erection grade, cavernosal artery diameter and peak systolic velocity post treatment compared with that of pre treatment. But, there was no remarkable difference between post treatment and follow up. While there was no significant difference between pre treatment versus after treatment and after treatment versus follow up of end diastolic velocity |