الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Seizures in the pediatric population commonly occur, and when proper rescue medication is not administered quickly, the risk of neurologic compromise emerges. For many years, rectal diazepam has been the standard of care, but recent interest in a more cost-effective, safe alternative has led to the investigation of intranasal midazolam for this indication. Although midazolam and diazepam are both members of the benzodiazepine class, the kinetic properties of these 2 anticonvulsants vary.
Benzodiazepines are the first-line agents for treatment of acute seizures, with diazepam, clonazepam, lorazepam, and midazolam being the most widely used of the class.
Various drugs administered through different routes have been tried in the management of acute seizures. Rectal diazepam has been used successfully for home and hospital treatment of acute seizures. Its use may be socially embarrassing and undesirable. Moreover, some special arrangement is required to administer it, which is difficult to arrange in homes, schools, and daycare centers. An effective treatment that can be easily administered by a more convenient, socially acceptable route is therefore needed Midazolam, a benzodiazepine, has been described as an alternative rescue medication in the management of acute seizures. Recent studies have demonstrated intranasal midazolam to be effective in the management of acute childhood seizures..