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Abstract Recently, drug targeting has been getting much attention by the researchers for treating cancer. Nanoparticles (NPs) as a key tool in targeted cancer treatment have been widely investigated, and they have shown promising potential. A critical advantage in treating cancer with NPs, as NPs featured a smaller particle size and a high surface area, they could enter the blood circulation via the capillaries and pass through the endothelial cell gap and migrate to the tumor site, thus achieving a drug-targeted distribution and enhancing the bioavailability of the drug. Moreover, NPs could control the release of the drug through the degradation of biomaterial in a long and smooth pattern, ultimately prolonging the eliminating half-life, improving the effective blood concentration, and reducing the dosing frequency. |