الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus is characterized by organ dysfunction arising from the effects of chronic hyperglycemia. The chronic complications of diabetes are classified as macro- or microvascular depending on the underlying pathophysiology. The microvascular triad of retinopathy, nephropathy and neuropathy is unique to diabetes. Inflammation plays an essential role in the progression of diabetic microvascular complications. Recently, serum osteoinductive factor a new marker has been studied for the early diagnosis of diabetic nephropathy.
This study included 90 subjects from Alexandria Main University hospital. They are classified as: 30 type 2 diabetic patients with normoalbuminuria, 30 type 2 diabetic patients with microalbuminuria and 30 type 2 diabetic patients with macroalbuminuria.
There was statistically significant difference between patients regarding serum OIF which decreased in patients with DN with positive correlation with eGFR CKD EPI and negative correlation with ACR and duration of DM.
Serum osteoinductive factor has the potential to be a new marker for screening patients at risk for early DN leading to increased prophylactic treatment in these patients