الفهرس 
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Abstract
This cross sectional study was performed to evaluate the level of nesfatin-1in serum of men affected with diabetes induced erectile dysfunction compared to diabetic patients with normal erectile function as well as healthy patients. It was conducted in Andrology and Internal medicine Departments of Beni-Suef University hospital (Beni-Suef, Egypt). This study encompassed 76 participants; 46 patients with T2DM (group I) and 30 diabetes free control subjects (group II). The patients answered a single item questionnaire, Erection Hardness Score, and according to the response obtained they were further divided into two subgroups (IA and IB) as diabetic patients with and without ED, respectively.
After statistical analysis, the results were as follows:
• The three groups were matched regarding their baseline characteristics. Serum nesfatin-1 levels were significantly lower in the group I and II compared to the controls.
• The IIEF-5 scores had shown significant correlations with serum nesfatin-1, serum testosterone, GAD-7, PHQ-9, EHS, DBP, HbA1c, triglycerides, creatinine and albumin/creatinine ratio (ACR).
• ROC analysis revealed that serum Nesfatin-1≥ 0.62 ng/ml, serum testosterone≥2.9 ng/ml, GAD-7 score ≥7.5, PHQ-9 score ≥5, HBA1C ≥6.4%, triglycerides ≥ 144 mg/dL, creatinine ≥ 0.85 mg/dL, and ACR≥ 26.5 are useful predictors of ED in men with T2DM, and the AUC for those variables was respectively 0.83, 0.76, 1, 0.75,0.88, 0.72,0.67,and 0.77.
• Finally, a linear regression analysis revealed that GAD-7 was the only strong independent predictor of IIEF-5 (p<0.001).