الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The in vitro study illustrated a synergistic (CI < 1) antioxidant capacity of PEE/CWE combination. Dexa exerts testicular damage by inducing oxidative reactions, a marked reduction in serum testosterone, TSH and LH levels, insulin resistance, ER stress and autophagy. In contrast, PEE and CWE extracts improve fertility hormones, sperm motility and the testicular histological alterations through attenuating oxidative stress, ER stress and autophagy with a synergistic effect upon combination.In conclusion: Dexa was found to negatively regulate the HPG (the hypothalamic pituitary gonadal) axis and suppress the secretion of LH and FSH, which in turn reduced testosterone production, consequently leading to depletion of fructose level and finally impairing the spermatogenesis function and the normal sperm motility. The current findings provide a novel insight into the mechanism of Dexa-induced testicular dysfunction in male rats. Besides the androgen deficiency, oxidative stress, ER stress, and autophagy hyperactivation play a crucial role in Dexa-induced testicular toxicity. Inhibiting oxidative stress and ER stress (reduced GRP87 and Sigma 1R) using PEE and CWE remarkably blocked Dexa-induced autophagy (elevated P-mTOR(S2448) and P62 levels and reduced ATG5, ATG7, PI3KC3, Beclin-1 and LC3II/LC3I expression levels). Interestingly, PEE/CWE combination proposed a synergistic (CI < 1) antioxidant and ameliorating capacity.