الفهرس 
A randomized controlled study comparing fluoroquinolone based sequential therapy versus clarithromycin triple therapy for the eradication of helicobacter pylori in Egypt
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Abstract
Aim: This study aimed at evaluating Moxifloxacin-based sequential therapy VS. Clarithromycin triple therapy as first line regimens for eradication of H-pylori. Methods: In this randomized clinical trial, 93 HP infected patients were randomly divided into two groups. Moxifloxacin based sequential regimen (group A); omeprazole and amoxicillin for 7 days followed by omeprazole, metronidazole and moxifloxacin for 7days.Clarithromycin based triple regimen (group B): omeprazole, amoxicillin and clarithromycin for 14days. Stool antigen test was used to evaluate HP eradication 6 weeks after the end of treatment.Compliance, drug side effects and dypepsia improvement were secondary outcomes.Results: Per protocol eradication rates of group A and B were 79.5% and 86% respectively. By intention to treat analysis, group A had an eradication rate of 68.9% while group B had an eradication rate of 77.1%. Conclusion: In this study,Triple therapy was more effective than moxifloxacin-sequential therapy. However, the difference was statistically insignificant. Studies with larger sample size are needed