الفهرس 
The hepatoprotective effect of casein glycomacropeptide as compared to pterostilbene and curcumi
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Abstract
This study was conducted to study the effect of feeding of casein glycomacropeptide (CGMP) on alleviating different stages of liver fibrosis developed in male adult Wistar albino rats by their injection with CCl4. Moreover, it was to compare the improvement effect of CGMP with the effect of pterostilbene and curcumin as a proposed effective polyphenols for treating liver fibrosis. Liver functions, liver histopathology and fibrotic parameters were examined. Also, the effect on kidney functions and histology were determined. Two experiments were carried out to study the following: The comparison between the beneficial effect of feeding CGMP (50 and 100 mg/kg), curcumin (100 mg/kg) and pterostilbene (15 and 40 mg/kg) on liver of rats injected with CCl4 for 5 weeks. Determination of the beneficial effect of feeding CGMP (150 mg/kg) on rats already developed liver fibrosis by their injection with CCl4 for 5 weeks before starting feeding. This was also compared with feeding rats with CGMP (150 mg/kg) coincided with CCl4 injection. CGMP (100 mg) and pterostilbene (40 mg) significantly improved liver functions with no significant differences between both items. Both significantly reduced liver enzymes ALT, AST and ALP, reduced MDA, LDH and bilirubin and increased the antioxidants CAT, SOD and GPx. Lower concentrations of both additives showed less improvement. Curcumin improved the above functions but with a lower percentage than pterostilbene (40 mg) and CGMP (100 mg). CGMP (150 mg/kg) significantly improved the functions of fibrotic liver and in particular ALT and greatly increased the antioxidants CAT, SOD and GPx than all other ingredients. This means a good reduction of oxidative stress in liver and might be proof that the effect of CGMP would last longer than the polyphenols