الفهرس 
ASSOCIATION OF miR-149 AND miR- 196a2 SINGLE NUCLEOTIDE POLYMORPHISM WITH ATHEROSCLEROTIC ISCHEMIC STROKE SUSCEPTIBILITY
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Abstract
Background: Genetic factors play an important role in determining the susceptibility to ischemic stroke, two variants in pre miRNA sequences rs2292832 and rs11614913 within miR-149 and miR-196a2 respectively are studied for their association with ischemic stroke while this relationship are still conflicting and inconclusive. Aim of the work: The aim of this study was to investigate the possible association of miR-149 and miR-196a2 genetic sequence variation with the risk of ischemic stroke and its outcome. The other goal was to clarify the ability of using these variants in risk stratification of atherosclerotic ischemic stroke. Subjects and Methods: A case{u2013}control study was conducted to evaluate the frequencies of both miR-196a2 T> C and miR-149 C>T allele variants using real-time PCR TaqMan probes. One hundred ischemic stroke patients recruited from stroke unit of Kasr Al Ainy Hospital. One hundred age and sex-matched control group with more than one risk factor for ischemic stroke with no evidence of cerebrovascular disease, ischemic heart diseases or peripheral arterial diseases. Results: the TT genotype and T allele frequencies of rs11614913 within miR-196a2 were associated with decreased risk of ischemic stroke while, CC genotype and C allele of rs2292832 within miR-149 was associated with increased risk of ischemic stroke in studied population. Conclusion: In this study an association was detected between the presence of miR-196a2 T allele and TT genotype with decrease incidence of ischemic stroke and declared an increases in the likelihood of the association between CC genotype and C allele within miR-149 and ischemic stroke