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Abstract Purpose:The aim of this study was to investigate the effect of moderate aerobic exercises on liver functions in students of university with non-alcoholic fatty liver.Subjects and methods: Sixty students were suffering from Non-alcoholic fatty liver disease (NAFLD) and they were recruited in this study with age ranged from 18-28 years old from both sexes 30 patients male and 30 patients female , were selected from internal medicine department at Zagazig university hospital and from students hospital in Zagazig. They were divided into two Groups equal in number. (group A= 30 students, 18 male and 12 female) received their standard medications and low calorie diet In addition to moderate aerobic exercises 3 times per week for 8weeks.(group B =(30 students 12 male and 18 female) received their standard medications in Addition to low calorie diet for 8 weeks. Lab investigations of: Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), and Triglycerides (TG) were applied to evaluate patients.Fatigue severity scale (FSS) and body mass index BMI were calculated for patients at two intervals (pre-treatment and post-treatment). Results: Statistical significance was set at P < 0.05. In (group A): there were significantly decrease of all variables at post treatment compared to pre-treatment with improvement percentage in BMI (8.6%), ALT(15.97%), AST (16.3%), TG (17.99%) and FSS(35.38%). in (group B): there were significantly decreased of all variables at post treatment compared to pre-treatment with improvement percentage in BMI(5.9%), ALT(11.4%) ,AST(7.68%) , TG (11.15%) and FSS(5.66%). In between groups post treatment, there were no significant difference in BMI, ALT, AST and TG. However, there was significant difference in FSS |