الفهرس 
Multi-component reactions of cyclohexan-1,3-dione for the synthesis of thiophene, pyrazole and pyran derivatives with antitumor activities
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Abstract
Cyclohexan-1,3-dione (1) which reacted with salicylaldehyde (2) and either malononitrile (3a) or ethyl cyanoacetate (3b) in ethanol containing a catalytic amount of triethylamine to give the 3,4,7,12b-tetrahydrochromeno[3,4-c]chromen-1-one derivatives 5a,b. The latter compounds underwent Gewald{u2019}s thiophene synthesis through the reaction with either malononitrile or ethyl cyanoacetate to give compounds 6a-d, respectively.The latter products underwent a series of heterocyclization reactions to yield pyran, pyridine, thiophene and pyrazole derivatives. The synthesized compounds were evaluated against the six cancer cell lines A549, HT-29, MKN-45, U87MG, and SMMC-7721 and H460 using the standard MTT assay in vitro, with foretinib as the positive control. Many compounds expressed high inhibitions