الفهرس 
Uses of dimedone to synthesis thiophene, azole and azine derivatives together with their cytotoxic evaluation
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Abstract
Reaction of dimedone (1) with arylaldehydes gave the benzylidene derivatives which underwent a series of heterocyclization reactions to give fused thiophene, pyrazole and isoxazole derivatives. while the reaction of dimedone with triethoxymethane give ethoxymethylene derivative which is used for the synthesis of derivatives of pyrazole, isoxazole, thieno[3,2-e]indazole, 6,7-dihydrobenzo[b]thiophene, arylaminomethylene-6,7- dihydrobenzo[b]thiophene. while the multicomponent reactions of dimedone is used to synthesize a series of thieno[3,2-f]chromene-8-carbonitrile, thieno[3,2-f]chromene, tetrahydrochromeno[2,3-c]pyrazol-5-one, hexahydroquinoline-3-carbonitrile, thieno[3,2- f]chromene-8-carboxylate derivatives. The synthesized compounds were evaluated against different kinds of cancer cell lines together tyrosine kinases and Pim-1 kinase inhibitions. Most of the synthesized compounds were assessed the inhibitory activities against A549 (non-small cell lung cancer), H460 (human lung cancer), HT-29 (human colon cancer) and MKN-45 (human gastric cancer) cancer cell lines together with foretinib as the positive control by a MTT assay. There are a group of promising compounds