الفهرس 
Measuring The Tissue Level Of Suppressor Of Cytokine Signaling-3 (SOCS-3) In Mycosis Fungoides Patients
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Abstract
Mycosis Fungoides (MF) is a low-grade cutaneous lymphoma accounting for more than half of all primary cutaneous lymphomas with an incidence of 5.6 per million. The clinical course of the disease is typically characterized by progression from a nonspecific phase of erythematous patches to the appearance of plaques and ultimately, in some patients, tumors. It is a multifactorial disease where genetic, environmental, immunological factors interplay in pathogenesis and tumor microenvironment changes of the disease. SOCS3 is one of the proteins expressed in malignant cells of CTCL cell lines but its exact role played in the disease has not yet been thoroughly investigated.Objectives: The aim of this study was to assess the expression of SOCS3 in the skin of patients with Mycosis Fungoides, to elucidate their possible role in the pathogenesis in MF Methods: Thirty patients with mycosis fungoides and thirty age and sex-matched healthy controls were included. Full clinical examination was done and tissue levels of SOCS3 were measured by ELISA technique.Results: In the current study, the level of expression of SOCS3 was significantly upregulated in the lesional tissue compared to peri-lesional SOCS3 level in patients{u2019} group (p<0.001) and both levels were higher than the SOCS3 level in control group (p<0.001). In addition, there was a statistically significant positive correlation between lesional SOCS3 level and itching in patients{u2019} group (p<0.05). Regarding lesional and perilesional SOCS-3 Levels in each stage, there is a significant increase in lesional SOCS-3 Levels in comparison to perilesional level whether in stage Ia, Ib and IIa; (p<0.001), (p<0.001) and (p<0.001), respectively