الفهرس 
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Abstract
Periodontitis is a multifactorial inflammatory illness associated with dysbiotic plaque biofilms and characterised by gradual destruction of the toothsupporting apparatus.
The relationship between periodontitis and diabetes mellitus is bidirectional and independent of risk factors; the two illnesses influence one another. Due to the fact that diabetic individuals are more prone to periodontitis due to decreased tissue repair and immuno-inflammatory response, the use of adjuvant medicines, including as antimicrobials and host response modulators, may address the unique therapeutic demands of this patient population.
Curcumin (diferuloylmethane), the primary yellow bioactive component of turmeric, has a wide range of biological effects, including anti-inflammatory, antioxidant, antibacterial, and antifungal characteristics, according to the scientific literature. Curcumin’s benefits on many malignancies and inflammation-related disorders, such as rheumatoid arthritis, pancreatitis, Crohn’s disease, inflammatory bowel disease, and type 2 diabetes, as well as its wound healing qualities, have been established in several research.
This study was done to examine the effect of sustained release curcumin on clinical indicators and total antioxidant capacity in the therapy of periodontitis in diabetic individuals.
In this study, 30 diabetes individuals of both sexes and ages ranging from 30 to 60 years were recruited. Patients were diagnosed with periodontitis in the second stage, while 10 healthy volunteers served as a control group. Patients with diabetes were randomly randomised to one of three SRP treatment groups: sustained curcumin, curcumin, or placebo gel. At baseline, 6 and 12 weeks after treatment, clinical parameters (plaque index, gingival index, probing depth, clinical attachment level) and total antioxidant capacity were measured.
Our research demonstrated an increase in clinical markers and overall antioxidant capacity over the course of 12 weeks. The sustained curcumin group had the greatest increase in clinical parameters and total antioxidant capacity, followed by the curcumin group and the placebo group.