الفهرس 
Ulcerative colitisOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Ulcerative colitis is a chronic inflammatory disease of the colon, characterized by attacks of remission and exacerbation, the diagnosis is suspected clinically and confirmed through endoscopic biopsy, it needs to be followed up and assessed by non-invasive biomarkers, one of these biomarkers is serum Matrix Metalloproteinase-9. MMP is an inducible protease that was shown to be upregulated in several inflammatory conditions. It has been found that MMP-9 is the most abundant MMP subtype in inflamed intestinal tissue of patients with inflammatory bowel disease (IBD).
Aim: To investigate the role of MMP-9 in monitoring activity and severity of Ulcerative Colitis.
Patients and methods: This is a prospective Cohort study which was conducted on 50 Egyptian patients with ulcerative colitis, divided into 2 groups: group 1 including 40 patients with active UC and group 2 including 10 patients with inactive UC, disease activity was measured according to the Mayo activity scoring index, serum MMP-9 and fecal Calprotectin were measured for all subjectcs using ELISA.
Results: As regards disease activity, fecal Calprotectin’s sensitivity and specificity were 90% at cut off value < 50 mg/kg with accuracy 95.5%, while serum MMP-9’s sensitivity and specificity were 97.5% and 100% respectively at cut off value < 47 ng/ml with accuracy 99.8%, and regarding disease severity, fecal Calprotectin’s sensitivity and specificity were 80% and 95% respectively at cut off value < 170 mg/kg with accuracy 88%, while serum MMP-9’s sensitivity and specificity were 95% and 100% at cut off value < 340 ng/ml with accuracy 98.7%.
Conclusion: Correlations of serum MMP-9 to Mayo activity scoring index were both higher than that of fecal calprotectin, implying that MMP-9 could be a good indicator for overall evaluation of mucosal inflammation combining severity and extent. So, MMP-9 has a better performance as compared with faecal calprotectin in evaluation of intestinal inflammation in UC. MMP-9 is a simple marker that can be helpful for differentiating active UC from inactive disease and a good guide for mucosal inflammation.