الفهرس | Only 14 pages are availabe for public view |
Abstract Metabolic syndrome (MetS) is a multifactorial disorder. Its homeostasis is maintained via an array of adipocytokines. Therefore, the study aims to explore the influence of MetS components on the pro/anti-inflammatory events, and antioxidant enzymes. Patients were divided into healthy and four MetS groups according to different criteria e.g. dyslipidemia obesity; hypertension and type 2 diabetes. Demographic data, biochemical assays, cytokines, and oxidative biomarkers were evaluated. Fifth group recorded a very highly significant elevation in triglycerides and cholesterol, while G.III have the lowest level of HDL. Antioxidant enzymes were dramatically decreased in MetS, in parallel to an elevation in the inflammatory markers IL-8, IL-23, IL-33, NF, NO and resistin, which came positively correlated to triglycerides, LDL, FBG and HbA1c levels. Dyslipidemic patients were observed with lowest levels of NF-κB and resistin as compared with other MetS cases. A positive correlation between pro-inflammatory markers IL-8; IL-23; resistin and NF-κB with triglycerides, LDL, FBS and HbA1c, and was negatively correlated with HDL-c, IL-33 and antioxidant enzymes. Keywords: Metabolic syndrome, hyperlipidemia, obesity, hypertension, hyperglycemia, cytokines, oxidative stress. |