الفهرس 
Ch. (1): Central nervous system infectionsOnly 14 pages are availabe for public view
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Abstract
The aim of this study was to evaluate the role of serum and CSF
heparin binding protein in early diagnosis of acute bacterial meningitis
and its efficacy in differentiating acute bacterial from non-bacterial
meningitis.
This study was conducted on 133 subjects included 65 patients
with acute bacterial meningitis, 48 patients with acute non bacterial
meningitis and 20 healthy persons of matched age and sex as controls.
Patients and controls were selected from inpatients and outpatients clinic
of Menouf Fever hospital in the period between January 2020 and April
2021. Patients were 58 (51.3%) males and 55 (48.7%) females and
controls were 8 (40%) males and 12 (60%) females, their ages were
ranging between 17-74years old. An informed consent was obtained
before patients entered the study.
Patients and controls were classified into the following groups:-
group 1: 65 patients with acute bacterial meningitis.
Group2: 48 patients with acute non-bacterial meningitis.
Group3: 20 volunteer subjects receiving spinal anesthesia for any
cause other than CNS as a control group.
Inclusion criteria: patients with suspected acute meningitis.
Exclusion criteria: Infections other than meningitis (UTI or chest
infection), patient receiving antibiotics more than 48 hours and any CNS
diseases except meningitis e.g (Cerebral haemorrhage or Post trauma or
stroke).
All patients were subjected to the following: Full history taking, full
general and neurological clinical examination and investigations including: Complete blood count, erythrocyte sedimentation rate, C
reactive protein, liver profile, kidney function testes ,serum Na and K,
blood glucose level , urine analysis and chest x ray.
CSF examination for
Chemical in the form of glucose, protein and lactate levels.
Microbiological in the form of culture for detection of bacteria.
Cytological examination in the form of: Total and differential
WBCs count.
Heparin binding protein was done both in serum and CSF at the
same time to all groups using Enzyme linked immunosorbant assay .