الفهرس | Only 14 pages are availabe for public view |
Abstract Hepatotoxicity is defined as injury or liver damage caused by exposure to drugs or other nonpharmacological agents. There is a wide spectrum of symptoms ranging from mild non-specific symptoms like asymptomatic transaminitis, acute hepatitis, chronic hepatitis and cholestasis to liver failure. There are many classes of drugs causing drug-induced liver injury including NSAIDs, anti-infective drugs, anti-cancer drugs, hormonal drugs, immunosuppressive agents, sedative and neuropsychiatric drugs. Bisphenol A is a high-production volume industrial chemical found in many consumer products. It induces oxidative stress and partial fat infiltration and inhibits cytochrome P450 isoforms in the liver of rats. The developmental exposure to BPA causes liver diseases, including hepatic steatosis, liver tumours and metabolic syndrome. Moringa oleifera belongs to the family moringaceae, is a small or middle sized tree, usualy grows 10-12 m in height. The extracts of leaves, seed and pod, have potent antidiabetic activity. Moringa ameliorated liver fibrosis in rats and reduces liver damage and symptoms of liver fibrosis, decreased the CCl4- induced elevation of serum aminotransferase activities and globulin level, and reduced the elevated hepatic hydroxyproline content and myeloperoxidase activity. The aim of this study was to evaluate the effect of M. oleifera leaves extract against BPA induced hepatic toxicity in rats. Results of the present study showed that: ? There were significantly higher serum levels of AST, ALT, blood sugar, MDA, TNF-?, MIF and significantly decreased serum levels of GSH in rats received BPA when compared to control group so, BPA lead to liver toxicity. ? There were significantly reduced serum activities of AST, ALT, blood sugar, MDA, TNF-? and MIF levels in rats received BPA with M. oleifera leaves extract at dose 200,400 mg/kg BW while, there were non significantly, significantly increased serum levels of GSH, respectively compared to rats toxicated by BPA. ? There were significantly reduced serum activities of AST, ALT and blood sugar levels while there were non significantly, significantly reduced serum levels of MDA, respectively in rats received M. oleifera leaves extract at dose 200,400 mg/kg BW for one month then toxicated with BPA compared to rats toxicated by BPA. ? There were non significantly, significantly increased serum level of GSH, respectively in rats received M. oleifera leaves extract at dose 200,400 mg/kg BW for one month then toxicated with BPA compared to rats toxicated by BPA. ? There were significantly reduced serum levels of TNF-? and non significantly reduced serum levels of MIF in rats received M. oleifera leaves extract at dose 200 mg/kg BW for one month then toxicated with BPA compared to rats toxicated by BPA. ? There were significantly reduced serum levels of TNF-? and MIF in rats received M. oleifera leaves extract at dose 400 mg/kg BW for one month then toxicated with BPA compared to rats toxicated by BPA |