الفهرس 
Anatomy of ovariesOnly 14 pages are availabe for public view
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Abstract
Background: We evaluated the sensitivity, specifcity and accuracy of fuorine-18-fuorodeoxyglucose with positron
emission tomography/computed tomography (18F-FDG-PET/CT) in a group of patients with suspicion of ovarian
cancer recurrence. It is considered a diagnostic dilemma, particularly in the 2 years following frst-line therapy. CA125
serum levels computed tomography (CT) and other modalities are used during routine follow-up. These traditional
modalities could provide a signifcant number of false-negative or equivocal results even in the presence of elevated
CA125 levels. So the performance of 18F-FDG-PET/CT is essential for the optimal diagnosis of recurrence and treat‑
ment planning.
Results: Studying PET/CT behaviour in the detection of ovarian cancer recurrence, 18F-FDG-PET/CT had an accuracy
of 98% with sensitivity and specifcity of 98% and 100%, respectively. 18F-FDG-PET/CT had a PPV of 100% and NPV of
83%. While studying the CA125 level (>35 U/ml) to detect the ovarian cancer recurrence during patient follow-up, the
CA125 level had an accuracy of 50% with a sensitivity ratio and specifcity ratio of 47% and 80%, respectively. CA-125
level had a PPV of 95% and NPV of 14%. In comparison between conventional CT and PET/CT studies, the PET/CT
diagnosed local tumor recurrence in 16 patients (32%), while CT scan diagnosed local tumor recurrence in only 3
patients (6%), and PET/CT detected peritoneal recurrence in 34 patients (68%). CT scan found peritoneal deposits
in 11 patients (22%), also the PET/CT showed suspicious abdominal LNS in 22 patients (44%) while, CT scan showed
suspicious abdominal LNS in 4 patients (8%), and PET/CT showed suspicious pelvic LNS in 16 patients (32%). CT scan
showed suspicious pelvic LNS in 7 patients (14%). PET/CT detected distant organ metastases in 18 patients (36%). CT
scan detected distant organ metastasis in only 8 patients (16%). Comparison between CT and PET/CT in 32 follow-up
cases for the detection of local tumor recurrence, peritoneal deposits, suspicious abdominal/pelvic LNs and distant
organ metastasis. There was a statistically signifcant diference between CT and PET/CT the end results (p<0.0001,
p=0.0047, p=0.001, p=0.03).
Conclusions: 18F-FDG-PET/CT is more sensitive in detection and localization of ovarian cancer recurrence and more
superior than the other imaging modalities.
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