الفهرس 
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Abstract
Paracetamol is one of the most commonly used OTC analgesic drugs. unfortunately it affects the liver function even in therapeutic dose. In case of paracetamol toxicity, N-acetyl cysteine (NAC) is the wellknown antidote, however it may cause an anaphylactoid reaction and also cannot be used in patients suffering from respiratory distress. Thus, there is a world trend toward natural products as an alternative to NAC. In this study, 60 male Wistar rats were divided into 5 groups. In early (7days) & late (28days) stages, paracetamol (PCM) was given daily for 7 days 1 hr. before drug administration. Gp. I received distilled water, Gp. II received paracetamol (600mg kg-1p.o.), Gp. III received PCM+ NAC (100mg kg-1p.o.), Gp. IV received PCM+ Wheat germ oil (WGO) (93 mg kg-1p.o.) and Gp. V received PCM+ Moringa oleifera (MO) (200mg kg-1 p.o.). ALT, AST, GSH, and MDA were assessed colorimetrically, serum levels of MPO & TNF-α assessed by ELISA, and HO-1 and NF-KB hepatic expression by immunohistochemistry.