الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
It has been suggested that hepatitis C virus (HCV) antigens are involved in the pathogenesis of psoriasis and may contribute to severity of the disease. Increased levels of the apoptosis-regulating proteins p53 of psoriatic patients have been reported.Aim : the aim of the study was to identify the serum levels of P53 in psoriatic patients with and without HCV infection to study the relation between clinical severity of psoriasis and the presence of HCV infection.Subjects and methods: This case control study comprised (28) patients diagnosed as psoriasis one of the differential diagnoses presented to the dermatologic outpatient clinic in Mansoura University Hospital. The cases were collected within during 6 months from May 2019 to October 2019.Results: According to severity measured by psoriasis area severity index score (PASI) score 5 patients (17.8%) were severe, 6 patients (21.5%) were mild, 17 patients (60.7%) were moderate. there was high significant increase P53 in Psoriasis group compared with control group. There was highly significant positive correlation between PASI score and P53 level. There was highly significant positive correlation P53 level and psoriasis affection .There was statistically significant increase in HCV Ab in psoriasis group. There was no statistically significant difference between HCV among degree of severity and P53. There was no correlation between age among severity and p53.Conclusion: These results conclude that clinical severity of psoriasis was affected by the presence of HCV antibodies and increase levels of apoptotic related proteins P53.