الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The present study is a prospective cross sectional study aimed to identify the proportion of complications and associated risk factors in pediatric patients with B-thalassemia major. The study included 183 pediatric patients The mean age of the studied participants was 9.34 ± 4.29 years and ranged from 2 to 18 years. Out of 183 patients, 85 patients were boys (46.4%) and 98 patients (53.6%) were girls. The median age of B-TM onset in our studied cases was 8 months and ranged from 6 to 24 months.About 17% of studied cases were irregular in receiving the blood transfusion. Only 33% underwent splenoectomy. 162 (89%) of our studied cases were wasted and 174 (95%) were stunted Splenoectomized patients have worse anthropometric measurement than patients with no splenoectomy. Older aged (>12 – 18 years) patients with splenoectomy have higher prevalence of jaundice, mongoloid face, hepatomegaly (P<0.001) as compared to younger aged children. Also older aged (>12 – 18 years) splenectomized patients especially those who perform splenoectomy from a remote period (>12 – 18) years were suffered from higher incidence of most types of complications as compared to younger aged children More than half of our studied patients were irregular in receiving their chelation therapy and have higher incidence of complications as a consequence Older aged patients and those who received iron chelation therapy irregulary were founded to be risk factors for developing different B-TM associated complications namely excessive skin pigmentation, cardiomyopathy, liver cirrhosis and osteoporosis. Meanwhile sex has no impact on developing complications The present results and other existing data show the impact of poor management of BT-M patients. Larger documented health education ongoing programs are needed to increase the awareness of children and their parent about the importance of receiving regular treatment and regular health care among children with BT-M for better outcomes and better quality of life among them. There is a vital need for the development of individualized interventions programs tailored to the physical and psychological well-being of pediatrics with acute BT-M in Assuit University.