الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 132 |  |  |
| | | from | 132 | | |
Abstract
Background and rationale: Nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin are used against inflammation and pain, however, serious adverse effects on the gastrointestinal tract can limit their use. They can cause serious mucosal injuries to the gastric mucosa, these injuries may be caused by blocking prostaglandin synthesis through inhibition of the cyclooxygenase (COX) enzymes. Sodium alginate nanoparticles induce a muco-protective effect by covering the surface of the gastrointestinal tract and elicit platelet aggregation. Therefore, it may be useful for the treatment of gastric ulcers. So far, there are no available histological studies that investigate the effect of sodium alginate nanoparticles on gastric mucosa.
Aim of the study: To protect the gastric mucosa against indomethacin induced gastric ulcer using sodium alginate nanoparticles. Materials and methods: This study will be carried out on 44 adult male albino rats that will be equally randomized into four groups as follow control group, sodium alginate nanoparticles group, indomethacin group, sodium alginate nanoparticles and indomethacin group. Stomach specimens will be processed for different histological and immunohistochemical techniques. Qualitative and quantitative assessment will be performed accordingly. The obtained data will be statistically analyzed using SPSS software version 22.