الفهرس 
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Abstract
The master thesis include aim of the work and three main chapters
I- Aim of the work
The work aimed to prepare and characterize new propane hydrazide
ligand and its metal complexes aiming to study their effects in the
treatment of tumor diseases.
II- Introduction
This chapter includes an overview of previous researches for
complexes of hydrazide ligands and their application.
III-Experimental
This chapter contains the used chemical and instruments in Practical
part of thesis as follow:
1) Preparation of propane hydrazide ligand and its metal complexes.
2) characterization of the ligand and its complexes using:
The ligand, (H3L) was prepared by dropwise addition 2-
aminopropanoic ester (20.0 g, 0.13 mol) dissolved in 30 cm3 of ethanol
to hydrazine (29.0 g, 0.26 mol) dissolved in 20 cm3 of ethanol solution
. The mixture was refluxed with stirring for 2 hours and then left to cool
at room temperature .filtered off the formed precipitate and leave it to
dry at room temperature. The ethanolic solution of the product (24.0g,
0.08 mol ) was added 3-acetyl-2-hydroxy-6-methyl-4H-pyran-4-one
(22.9g, 0.17 mol) (1:2) dissolved in 30 cm3 ethanol . The mixture was
stirred and refluxed for another three hours at 80 0C, then left to cool at
room temperature. The solid product was filtered off, then dried under
vacuum over anhydrous CaCl2 to give the ligand.
(E)-N’-(1(6methyl2,4dioxo3,4-dihydro-2H-pyran-3yl)ethylidene)2((E)
(1(6methyl2,4dioxo3,4dihydro2Hpyranyl)ethylidene)amino) propane
hydrazide
The reaction of the ligand (H3L) with Cu(II), Ni(II), Co(II), Zn(II) ,Ba
(II) and Mn(II) complexes have been synthesized and characterized by
(1H-NMR, mass, IR, UV-VIS, ESR) spectroscopy, (magnetic moments,
conductance) measurements, (elemental and thermal) analysis. The IR
spectral data show that, the Schiff base behaves as a neutral tetra
dentate ligand bonded to the metal ions through the azomethine nitrogen
atom and Sulphur atom in thiocarbonyl group which protonated or
deprotonated form adopting either octahedral or tetragonally distorted
octahedral geometries. Molar conductance in DMF solution indicates
that, the complexes are non-electrolytes. The ESR spectra of solid Cu
(II) complexes (4,13, &19) show an axial type indicating a d(X2-y2) or
d
(Z2) ground state with a significant covalent bond character. However,
Co (II) complex (17) show isotropic type indicating an octahedral
geometry. Cytotoxic evolution of the ligand and its complexes have
been carried out. Complexes show enhanced activity in comparison to
the parent ligand. Metal complexes (4),(5),(6),(7),(17) and (19) were
evaluated against MCF-7 cell line showed better chemotherapeutic
effect against MCF-7 cell line than the standard drug used. Also, the Co
(II) complex (17) shows the highest potency of inhibition at 250 µg/ml
against MCF-7