الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Hepatopulmonary syndrome (HPS) is a triad of liver disease, pulmonary gas exchange abnormalities leading to arterial deoxygenation, and widespread pulmonary vascular dilatation which can be detected by transthoracic agitated echocardiography. The aim of this study was to study the prevalence and predictive values of various cut offs for arterial oxygenation and their clinical consequences in diagnosis of hepatopulmonary syndrome. Descriptive cross-sectional study that comprised 100 patients with liver cirrhosis in Chest Department and Tropical and infectious diseases Department, Tanta University Hospitals, included 68 male and 32 females with mean age 60.48±10.24 and Mean body mass index 28.50±2.43. Patients with Hepatocellular carcinoma, chronic obstructive pulmonary disease, Interstitial lung disease and Congestive heart failure were excluded from this study. Patients accepted to participate in study were done History taking and complete physical examination, Agitated Echocardiography, Liver function tests, Arterial blood gases: by percutaneous radial artery puncture with the subject in seated position breathing room air, including PaO2, AaDO2 is calculated using the alveolar gas equation, Pulmonary function tests: including FEV1 and Chest X-ray ”PA and lateral view”. Patients were divided into two groups as follows: • group I: Hepatopulmonary group (Patient No. 7). • group II: Non-Hepatopulmonary group (Patient No. 93). This study showed statistically non-significant difference between HPS group and No HPS group regarding age, sex, BMI and smoking with p value > 0.05. This study showed statistically significant difference between HPS group and No HPS group regarding Etiology of cirrhosis with p value = 0.034 This study showed statistically significant difference between HPS group and No HPS group regarding platypnea and orthodoxia with p value = 0.0001 however our results showed statistically nonsignificant difference regarding ascites, Palmar erythema and spider naevi. This study showed statistically significant difference between HPS group and No HPS group regarding Bilirubin with p value = 0.025 also, regarding albumin with p value = 0.04. This study showed statistically significant difference between HPS group and No HPS group regarding Child score with p value = 0.034 and showed that child score was higher in HPS. This study showed statistically significant difference between HPS group and No HPS group regarding AaDO2 and FEV1 with p value = 0.008 and 0.03 irrespectively. This study showed statistically non-significant difference between HPS group and No HPS group regarding Chest radiograph with p value > 0.05 This study showed statistically significant difference between HPS group and No HPS group regarding Positive agitated ECHO with p value = 0.0001 Also, showed statistically significant positive correlation between AaDO2 and S.Bilirubin, ALT, AST and Child score. This study showed statistically significant negative correlation between AaDO2 and FEV1. This study showed statistically significant negative correlation between FEV1 and AaDO2, Age, ALT, AST and Child score.