الفهرس 
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Abstract
Thrombin-activatable fibrinolysis inhibitor (TAFI) is a fibrinolysis inhibitor(Hendriks et. al., 1989). It circulates as a procarboxypeptidase B zymogene, which is converted into an active form, TAFIa, during coagulation (Eaton et. al., 1991). TAFI activation is catalyzed by the thrombin/thrombomodulin complex, which is generated during coagulation (Bajzar et. al., 2000). When activated, TAFI suppresses fibrinolysis through cleavage of carboxy terminal lysine residues that are expressed during proteolysis of the fibrin polymers, which are the binding sites for plasminogen (Nesheim et. al., 1997).
The aim of this case control study was to assess the relation between Thrombin Activatable Fibrinolysis Inhibitor antigen and myocardial infarction. Patients included in the current study were divided into two groups; group 1: 44 patients were taken from those attending Suez Canal university hospital Cardiology follow up clinic from patient showed basal and clinically stable coagulation conditions, at least 3 months after the MI, group 2: 44 normal healthy controls.
The study showed that smoking,hypertention,diabetes mellitus and dyslipidemiaas risk factors were statistically significant in patient group than normal control group(p value =0.03,0.01,0.01and0.0002 respectively).
The result of the present study revealed that TAFI antigen level in myocardial infarction patients was statistically significantly lower than in control group(p value =<0.0001**) with mean value was (62.2±27.8) in myocardial infarction patients and mean value was (83.9±21.5) in control group which mean that according to this study TAFI has a protective effect in MI .
The study also investigated the High-sensitive C-reactive protein level and it was higher in myocardial infarction patients than control group but was not statistically significant.
In conclusion, the current study showed that patients with a recent MI presented lower values of TAFI Ag. Whether or not the lower TAFI Ag was the cause or the consequence of the MI requires investigation .However, more studies on the relationship between the TAFI antigen level and myocardial infarction are wanted.