![]() | Only 14 pages are availabe for public view |
Abstract Trichinella spiralis (T. spiralis) is one of the parasitic nematodes of highly zoonotic importance. It infects various vertebrates, including human. Trichinella spiralis is a highly pathogenic species affecting human. The present study was conducted to assess the nematocidal activity of tannic acid (TA) and albendazole (ABZ) individually or in combination during the intestinal phase and muscular phase of T. spiralis. In this study one hundred and sixty (n =160) Swiss albino mice were used, where eighty mice of them were experimentally infected by 300 larvae of T. spiralis. Mice were divided into 10 equal groups 8 mice for each, (control): non-infected but received saline, (ABZ): non-infected and treated with ABZ 50 mg/kg, (TA1000): noninfected and treated with TA1000 µg/ml, (TA2000): non-infected and treated with TA2000 µg/ml, (ABZ+TA2000): non-infected and treated with ABZ 50 mg/kg + TA2000 µg/ml , (TS): infected non treated, (TS+ABZ) group: infected and treated with ABZ 50mg/kg, (TS+TA1000): infected and treated with TA1000 µg/ml, (TS+TA2000): infected and treated with TA2000 µg/ml and (TS+ABZ+TA2000): infected and treated with ABZ 50mg/kg + TA2000 µg/ml. Mice for the intestinal phase were sacrificed at 7th day post-infection and for the muscular phase were sacrificed at the 49th day post-infection. |