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العنوان
Comparative Pathological Studies on The Protective Effect
of Albendazole and Tannin on Trichinella spiralis Infection
in Mice /
المؤلف
Mohammed, Shimaa Swilam Abbas.
هيئة الاعداد
باحث / Shimaa Swilam Abbas Mohammed
مشرف / Sary Khaleel Abd Elghaffa
مشرف / Nani Nasreldin Abdelaziz Farag
مشرف / Nani Nasreldin Abdelaziz
الموضوع
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تاريخ النشر
2022.
عدد الصفحات
245 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
البيطري
الناشر
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة الوادى الجديد - كلية الطب البيطري - الباثولوجيا والباثولوجيا الإكلينيكية)
الفهرس
Only 14 pages are availabe for public view

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from 245

Abstract

Trichinella spiralis (T. spiralis) is one of the parasitic nematodes of highly
zoonotic importance. It infects various vertebrates, including human.
Trichinella spiralis is a highly pathogenic species affecting human. The
present study was conducted to assess the nematocidal activity of tannic acid
(TA) and albendazole (ABZ) individually or in combination during the
intestinal phase and muscular phase of T. spiralis. In this study one hundred
and sixty (n =160) Swiss albino mice were used, where eighty mice of them
were experimentally infected by 300 larvae of T. spiralis. Mice were divided
into 10 equal groups 8 mice for each, (control): non-infected but received
saline, (ABZ): non-infected and treated with ABZ 50 mg/kg, (TA1000): noninfected and treated with TA1000 µg/ml, (TA2000): non-infected and treated
with TA2000 µg/ml, (ABZ+TA2000): non-infected and treated with ABZ 50
mg/kg + TA2000 µg/ml , (TS): infected non treated, (TS+ABZ) group:
infected and treated with ABZ 50mg/kg, (TS+TA1000): infected and treated
with TA1000 µg/ml, (TS+TA2000): infected and treated with TA2000 µg/ml
and (TS+ABZ+TA2000): infected and treated with ABZ 50mg/kg + TA2000
µg/ml. Mice for the intestinal phase were sacrificed at 7th day post-infection
and for the muscular phase were sacrificed at the 49th day post-infection.