الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Acute kidney injury (AKI) is a global health problem. Organ dysfunction remains the third leading cause of death in trauma patients. Among organ failure after trauma AKI is common, with reported incidence up to 50%. AKI after trauma is a major complication independently associated with a prolonged hospital stay and increased mortality (Bierl, 2022) & (Cole, et al., 2022). The Aim of this study: The purpose of this study is to determine the incidence and the associated risk factors of AKI in severe trauma patients and its outcome in the emergency ICU. Materials and methods: This was a prospective observational analytical clinical study (cohort) carried out on 104 patients who were presented by severe trauma to Emergency department in Mansoura University Emergency Hospital (MUEH) from entrance to the emergency room and after admission to ICU. This study was conducted over the period of 1 year (from December 2020 to December 2021). Results: The current study revealed that the median age of the AKI cases was 47 while non-AKI cases was 26. The overall incidence of AKI within the studied population was (46.2%). Comorbid diseases were more common in AKI group than non-AKI group (41.7% vs. 21.4%). The vital signs were worse in patients with AKI than non-AKI patients. This was deterioration of renal functions in AKI than non-AKI groups. Predictors of AKI among sever trauma patients included sepsis, shock, rhabdomyolysis, coagulopathy and nephrotoxic drugs. The outcome of the studied cases was worse in patients with AKI as cases with AKI had more need for RRT, mechanical ventilation, vasopressors, more length of hospital stay and higher mortality rate with significant statistical differences between the 2 study groups. Conclusion: The causes of AKI in trauma patients are multifactorial. Development of AKI after severe trauma is closely associated with increased mortality and hospital length of stay. Early detection of AKI and management of risk factors of AKI can improve the outcome.