الفهرس 
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Abstract
This look at become accomplished in parts (in-vitro & in-vivo).
The in-vitro part of this research was finished to compare among two distinct sealers (AH Plus Jet sealer and total Fill bioceramic sealer as regard cytotoxicity, pH, Calcium ion release and adaptation.
As regard cytotoxicity, 24 samples had been prepared and divided into 2 groups in step with the type of sealer examined (12 samples every). A bad manipulate institution turned into utilized: fibroblasts cells with best way of life medium. Cytotoxicity was evaluated by means of the MTT Assay.
Concerning pH & calcium ion release, 30 samples have been examined using polyethylene tubes, they were divided into 2 groups in keeping with the sort of sealer examined (15 samples each). For the pH evaluation, the pH turned into measured with pH meter formerly calibrated with answers of known pH (four, 7, and 10). Opinions have been accomplished at durations of three, 5, 7 and 14 days.
Calcium ion release become measured the usage of an atomic absorption spectrophotometer. The readings of Ca ion launch were achieved on the same periods of the pH readings at three, 5,7,14 days.
To evaluate adaptability, 10 anterior enamel had been used (five teeth for every sealer tested). They have been organized and obturated to the working length, then in the end stored for 7 days at 370C in 100% humidity. Samples have been split into two longitudinal halves using a chisel. Version turned into evaluated the usage of scanning electron microscope.