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Abstract Across-sectionalstudy,whichincluded98pregnantwomenwhohadahighriskofectopicpregnancyinthefirsttrimesterofpregnancywhoattendedtothe outpatientdepartmentandpresentedwithlowerabdominalpainand/orvaginalbleedingatobstetricsandgynecologydepartmentinSuezcanaluniversityhospitalsandSuezgeneralhospitalfromOctober2016toAugust2017. TheaimofthestudywastodeterminewhetherserumlevelofCPK-MBinthefirsttrimesterofpregnancycanbeusedasapredictorofectopicpregnancyornot. SerumlevelCPK-MBwasmeasuredthroughavenousbloodsample.Thebloodsampleswerecentrifugedtoseparatetheserum.CPK-MBwasmeasuredbyenzymaticimmune-inhibitiontestby(CK-MBR)kitswhichismanufacturedby(SPINREACTCOMPANY)andusingBiosystemBTS350autoanalyzer. Theresultsofthestudyshowedthefollowing: 1. Serumcreatine phosphokinase(CPK-MB)wassignificantlyincreasedinwomenwithEPcomparedtowomenwithnon-ectopicpregnancyinthefirsttrimesterwithhighsensitivityandSpecificity. 2. SerumCPK-MBlevelwas(31–41IU/L)inectopicgroup,and(7–19IU/L)innon-ectopicgroup |