الفهرس 
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Abstract
Schizophrenia (SCZ) is a destructive neurodevelopmental disorder that influences approximately 1% of the population (Stilo and Murray, 2010). SCZ is a neuropsychiatric disease characterized by positive, negative and cognitive symptoms appearing at different schedules of the disease progression (Insel, 2010). Positive symptoms (paranoia, delusions, grandiosity and hallucinations) are the most prominent symptoms of the disorder. SCZ patients also present with prominent negative signs including, emotional withdrawal, social avoidance and blunted affect (Donegan and Lodge, 2017). Furthermore, the beginning of cognitive impairments arises during the early developmental stages and persists during the entire progression of SCZ and thus the best predictor of long-term functional consequence is cognitive deteriorations (Cannon, 2015). Three fundamental biochemical hypotheses, including dopamine, glutamate and gamma aminobutyric acid (GABA) hypotheses were implicated in the pathogenicity of SCZ, each hypothesis focusing on one of the main neu-rotransmitters implicated in SCZ development (Graham et al., 2016).
Bisphenol A (BPA) is a prevalent xenoestrogen, to which human is often exposed throughout daily life. It is used in the production of polyvinyl chloride plastics, compact discs, thermal fax paper, paint, baby bottles, drinking flasks, feeding bottles and even medical equipment, which are the major sources of daily exposure (Rochester, 2013). Possibly, one of BPA’s characteristics is its ability to cross the blood brain barrier (BBB), which can illustrate the intervention of BPA in the development of neurons, particularly in the cerebellum (Mathisen et al., 2013), prefrontal cortex, hippocampus (Khadrawy et al., 2016) and hypothalamus (Kinch et al., 2015). Moreover, it has been mentioned that persistent exposure to BPA have profound impacts on learning and memory (Jasarevic et al., 2013; Johnson et al., 2016) and depression (Xu et al., 2015a). Several studies linked the reciprocal neurotoxic effects of BPA to its potency to perturb the signaling of estrogen receptor (ER) in developing neurons leading to thumping proliferation and differentiation of neurons (Delfosse et al., 2012), manufacturing of endogenous estrogen (Chung et al., 2011), disruption of ER nuclear translocation (Xu et al., 2014) and modifying the genetic and epigenetic programming (Kundakovic et al., 2013.