الفهرس 
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Abstract
Our experiment was conducted to study the efficacy of twoantioxidants (Curcumin and Alpha lipoic acid) on the amelioration of the adverse effects of aflatoxin (AF 100 ppb) in broiler chickens fed on a starter and finisher ration which include the aforementioned level of aflatoxins, and compare this efficacy with that of a mycotoxin binder (Agrimos®). One hundred and twenty five one-day-old broiler chicks were randomly divided into 5 groups (25 birds/group). In this study the different treatments in theexperiment illustrated as follow:
group 1: Control negative.group 2: Control positive group fed on 100 ppb AF contaminated diet.group 3: Fed on 100 ppb AF contaminated diet and supplemented in diet with curcumin (1g |kg). group 4: Fed on 100 ppb AF contaminated diet and supplemented in diet with alpha lipoic acid (300mg|kg).group 5: Fed on 100 ppb AF contaminated diet and supplemented in diet with Agrimos® (1g|kg).
The followings parameters were measured to evaluate:
1- Performance parameters including body weight (BW), Feed conversion ratio (FCR), and mortality rates.
2- Pathological parameters including clinical findings of birds, gross lesions, histopathological lesions and relative weight of the liver, kidney and immune organs of the euthanized birds.
3- Biochemical parameters (liver enzymes, serum protein and kidney function tests).
4- Estimation of humoral immunity against ND vaccination.
Results of experiment can be summarized as follow:
The dietary supplementation of Curcumin and Agrimos® recovered the detrimental effects of AF contaminated diet on the broilers’ body weight. The dietary supplementation of Curcumin, Lipoic acid and Agrimos® recovered the detrimental effects of AF contaminated diet on the broilers’ feed conversion ratio.The lowest mortality rate was recorded in Lipoic acid group (4.16%) followed by Agrimos®treated group (8.33%), Curcumin treated group (12.5%) then control positive group (25%)but there was no mortality recorded in control negative group during the experiment.G3, G4 and G5 showed decrease in the reported clinical findings of morbid chickens, gross lesions and histopathological lesions of the dead and euthanized birds along the experiment. In addition, the relative weights of the liver in these groups showed significant improvement when compared with the control positive group.At the end of the experiment, use of Agrimos® in feed of intoxicated chicks significantly reduced the negative effect of the diets contaminated with aflatoxin on the relative weight of kidney and spleen, while the use of Curcumin in feed of intoxicated chicks significantly reduced the negative of the diets contaminated with aflatoxin in relative weight spleen.Use of Curcumin, Lipoic acid and Agrimos in feed of intoxicated chicks ameliorated the negative effects of the diets contaminated with Aflatoxin in liver enzymes, serum protein and creatinin. The antibody titers against ND vaccination enhanced significantly in the intoxicated chicks with the addition of Lipoic acid and Agrimos® into the AF contaminated diets, but addition of curcumin didn’t showed any significant improvement in ND antibody titers.
In this study, control negative group recorded the best BW and FCR values with no mortalities. No clinical signs, gross lesions and histopathological lesions reported in the euthanized birds from this group along the experiment.