الفهرس 
Design, synthesis and biological evaluation of substituted imidazolin-5-one derivatives
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Abstract
Cancer is considered one of the most serious human diseases in the world; therefore, cancer drug discovery is one of the most rapidly changing areas of pharmaceutical research. Imidazolin-5-one ring is one of the important 5-membered heterocycles that exhibited various biological and pharmacological activities. Accordingly, 3 series of novel 1,2,4-trisubstituted imidazolin-5-one derivatives were synthesized. The in vitro enzyme inhibitory activity against p38Ü mitogen-activated protein kinase (p38ÜMAPK) was performed. Additionally, in vitro anticancer activity of the newly synthesized compounds against liver cancer cell line (HepG2) was investigated. Also, molecular docking study was included to explore the compounds binding mode in the active site of p38ÜMAPK enzyme. The thesis consists of the following parts: 1.Introduction: This part includes a brief introduction of cancer, the cell cycle and different cancer treatment strategies based on the mechanism of action. Also, this part includes different pharmacological activities of imidazolinones and different methods for their chemical synthesis. 2.Aim of the work: This part illustrates the scientific basis on which the synthesized compounds were designed in order to explore the potential anticancer activity of the synthesized compounds