الفهرس 
Design, synthesis and molecular modeling study of some thiazolidinone derivatives as NS5B polymerase inhibitors
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Abstract
Hepatitis C virus (HCV) infection is a major global health challenge; it is estimated that more than 80 million people are chronically infected worldwide, 3{u2013}4 million new infections and 350 000 deaths occurring each year because of HCV-related complications.This thesis deals with the design and synthesis of some thiazolidinone derivatives to be evaluated as HCV-NS5B polymerase allosteric inhibitors. In addition, the anti-HCV activity was carried out for the new derivatives using a highly permissive subclone of the human hepatoma cell line Huh-7.5. Molecular docking studies were carried out to predict the possible binding mode of the newly synthesized compounds with HCV-NS5B polymerase to study their interaction with the enzyme key amino acids in a trial to explain their observed activity. Furthermore, key molecular characteristics were calculated to assess their drug-likeness potential