الفهرس | Only 14 pages are availabe for public view |
Abstract Cyanobacteria are known as a potential source of several metabolic compounds like phytohormons, phenols, amino acids, fatty acids, alkans as well as pharmaceuticals. These compounds are reported to be used in agriculture, biology and medicine. This study was performed to isolate Anabeana, Nostoc and Fischerella sp, from river Nile, Egypt. Also, their potential to produce some bioactive compounds were evaluated. Results indicated that Fischerella BS1-EG isolated during this study as well as other Anabeana and Nostoc isolates have a considerable antifungal activity against Aspergillus, Fusarium and Penicillum sp. In general, the determined fungal activities by means of inhibition zone ranged from 6.8-16 mm. Regarding the cell cytotoxicity of Anabaena, Nostoc and Fischerella BS1-EG cultures on liver cancer (HepG-2), lung cancer (A549), colon cancer (HCT-116), breast cancer (MCF-7), data indicated that all cyanobacterial crude extracts exhibited a variable influence on all tested cell lines. GC-MS analysis showed that 31 different compounds were detected and identified as fatty acids, alkaloids, phenols, amino acids. The most important 14 compounds were identified as anticancer, antimicrobial, antiinflammatory agents. Also 26 different compounds and the most important 15 compounds from Anabeana Qr and 22 compounds from Nostoc Sh1 and the most important 9 compounds having different biological activites |