الفهرس 
Teratogenic Effects of Antidepressant Drug Trazodon on the Development of Albino Rat Fetuses
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Abstract
Teratogenicity or reproductive toxicity refers to any deviation from normal development during prenatal period that may result from exposure to specific chemical, physical, environmental or even infectious agents during pregnancy. Trazodone is an antidepressant drug of the serotonin antagonist and reuptake inhibitor. Antidepressant drugs have been widely used during pregnancy. However, most studies reported several birth defects that result from using these drugs, there is not enough information about the risk or safety of trazodone using in pregnancy. Therefore, this work was initiated to study the effect of prenatal exposure of trazodone HCL on fetuses of albino rats. Mated female albino rats (Rattus norvegicus) were administrated during organogenesis period with therapeutic dose. At 20th day of gestation the pregnant rats were decapitated, cesarean section was done and fetuses were removed from the uterus and evaluated for mortality rate, growth parameters, morphological and skeletal malformation as well as histopathological study of the placenta, fetal liver, kidney and brain. Results showed fetal growth retardation during gestational period. Hematoma and deformation of limbs were noticed in the fetuses of treated groups. Fetal skeletal abnormalities were also observed mainly in the ribs included defective ossification, costal separation and wavy ribs