الفهرس 
English Cover
AbstractOnly 14 pages are availabe for public view
 |  | from | 127 |  |  |
| | | from | 127 | | |
Abstract
Influenza A viruses (IAVs) are important pathogens of humans and many other species, as, these viruses have been widely circulating in animals are novel to the human immune system; so pose a potential threat to public health. Moreover, recently, low-pathogenic avian influenza viruses (LPAIVs) have caused a global concern to public health therefore attention should be paid to the potential threats to humans posed by LPAIVs. As well as there is an urgent need to more efficient strategies for the prevention and control of such infection. Double stranded ribonucleic acid (dsRNA) has been shown to act as a ligand for Toll like receptor (TLR3) that known to induce type 1 interferons (IFNs) and pro-inflammatory mediators leading to antiviral response against many viral infections. Yet, its effectiveness and involved mechanisms as a mediator against low LPAIV have not been investigated adequately. Therefore, this study was attempted to investigate the effect and mechanism of dsRNA as anti-H₄N₆ LPAIV. Among those, the pre-hatch treatment of specific pathogen free eggs (at 18 days) with dsRNA was performed and evidenced the reduction of H4N6 replication in lungs by plaque assay